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Phytother Res. 2007 Sep;21(9):898-9.

Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells.

Author information

1
Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt. sayedaar@yahoo.de

Abstract

The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.

PMID:
17582594
DOI:
10.1002/ptr.2177
[Indexed for MEDLINE]

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