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Clin Infect Dis. 2007 Jul 15;45 Suppl 1:S29-33.

The genome of Salmonella enterica serovar Typhi.

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  • 1The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

Abstract

The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ~5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal) and that they emerged from a single point of origin ~30,000-50,000 years ago. Evidence suggests that, as well as undergoing gene degradation, S. Typhi has also recently acquired genes, such as those encoding the Vi antigen, by horizontal transfer events.

PMID:
17582565
DOI:
10.1086/518143
[PubMed - indexed for MEDLINE]
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