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Nature. 2007 Jun 21;447(7147):941-50.

Base-excision repair of oxidative DNA damage.

Author information

1
Department of Chemistry, University of California at Davis, 1 Shields Avenue, Davis, California 95616, USA. david@chem.ucdavis.edu

Abstract

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a constant challenge for living organisms. Base-excision repair has an important role in preventing mutations associated with a common product of oxidative damage to DNA, 8-oxoguanine. Recent structural studies have shown that 8-oxoguanine DNA glycosylases use an intricate series of steps to locate and excise 8-oxoguanine lesions efficiently against a high background of undamaged bases. The importance of preventing mutations associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylase MUTYH and colorectal cancer. The properties of other guanine oxidation products and the associated DNA glycosylases that remove them are now also being revealed.

PMID:
17581577
PMCID:
PMC2896554
DOI:
10.1038/nature05978
[Indexed for MEDLINE]
Free PMC Article

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