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Mol Microbiol. 2007 Jul;65(1):21-6.

Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization.

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Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Boston, MA 02115, USA.


Chromatin immunoprecipitation (ChIP) is a powerful method to measure protein-DNA interactions in vivo, and it can be applied on a genomic scale with microarray technology (ChIP-chip). ChIP-chip has been used extensively to map DNA-protein interactions across eukaryotic chromosomes. Here we review recent applications of ChIP-chip to the study of bacteria, which provide important and unexpected insights into transcription and chromosome organization.

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