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Regulation of excitability by potassium channels.

Author information

1
Institute for Neural Signal Conduction, Center for Molecular Neurobiology, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. morin@zmnh.uni-hamburg.de

Abstract

Neurons express a large number of different voltage-gated potassium (Kv) channels with distinct biophysical and biochemical properties. Possibly, this diversity reflects the need to regulate and fine-tune neuronal excitability at various levels of complexity in space and time. In this context, Kv channels operating in the subthreshold range of action- potential firing are of particular interest. It is likely that these Kv channels play a prominent role in both propagating and integrating dendritic signaling, as well as axonal action-potential firing and propagation.

PMID:
17579818
DOI:
10.1007/400_2007_032
[Indexed for MEDLINE]

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