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Mol Biosyst. 2007 Jul;3(7):458-65. Epub 2007 May 23.

Inhibition of lysine biosynthesis: an evolving antibiotic strategy.

Author information

  • 1School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia. chutton@unimelb.edu.au

Abstract

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.

PMID:
17579770
DOI:
10.1039/b705624a
[PubMed - indexed for MEDLINE]
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