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FEMS Immunol Med Microbiol. 2007 Aug;50(3):324-9. Epub 2007 Jun 18.

Capsule genes of Streptococcus pneumoniae influence growth in vitro.

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Institute for Infectious Diseases, University of Bern, Bern, Switzerland.


Recently, we showed that the in vitro lag phase correlates with the pneumococcal serotype. This study investigated the role of capsule genes in bacterial growth using strain D39. Deletion of the entire capsule operon induced a significantly prolonged lag phase in Todd Hewitt broth (P=0.0002). However, partial deletions showed a different influence on the lag phase. Supplementation of media with 5% fetal bovine serum restored normal growth, at least partially, in mutants with a prolonged lag phase. Therefore, pneumococcal capsule gene products influence bacterial growth in vitro in strain D39.

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