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Int Orthop. 2008 Oct;32(5):567-71. Epub 2007 Jun 19.

Compressive osseointegration promotes viable bone at the endoprosthetic interface: retrieval study of Compress implants.

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Orthopaedic Oncology Service, UCSF Comprehensive Cancer Center, San Francisco, CA 94115-1939, USA.


The Compress implant (Biomet, Warsaw, IN) is an innovative device developed to enable massive endoprosthetic fixation through the application of compressive forces at the bone-implant interface. This design provides immediate, stable anchorage and helps to avoid the long-term complication of aseptic loosening secondary to stress shielding and particle-induced osteolysis seen in conventional, stemmed megaprostheses. The purpose of our study was to evaluate the in vivo biological effects of the high compressive forces attained. Twelve consecutive Compress patients undergoing revision surgery for infection, periprosthetic fracture, or local tumour recurrence were reviewed in order to exclude the possibility of osteonecrosis at the prosthetic interface. Compressive forces ranged from 400-800 lb. Duration of implantation averaged 3.3 years (range 0.4-12.2 years). Two patients with infection demonstrated loosening at the bone-prosthetic interface; otherwise, there was no radiographic evidence of prosthetic failure in any of the patients. No patient demonstrated histological evidence of osteonecrosis. In fact, new woven bone and other findings consistent with viable bone were noted in all of the retrieved specimens.

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