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Cancer Res. 2007 Jun 15;67(12):5579-82.

Tumorigenesis in the brain: location, location, location.

Author information

1
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. Richard.Gilberston@stjude.org

Abstract

Emerging evidence from numerous laboratories supports the notion that brain tumors arise from cells with stem cell/neuroglial progenitor cell properties ("cancer stem cells"). Two recent studies suggest that histologically similar tumors from different brain regions are molecularly distinct because they arise from distinct populations of site-restricted progenitor cells. These new findings imply an interaction between the cell of origin, the tumor microenvironment, and specific cancer-causing genetic changes in the evolution of central nervous system tumors.

PMID:
17575119
DOI:
10.1158/0008-5472.CAN-07-0760
[Indexed for MEDLINE]
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