Format

Send to

Choose Destination
Am J Respir Crit Care Med. 2007 Aug 15;176(4):327-32. Epub 2007 Jun 15.

Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging.

Author information

1
The Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia 3010. smazzone@florey.edu.au

Abstract

RATIONALE:

Coughing in humans is typically preceded by a desire (or urge) to cough. The neural circuitry involved in sensing airway irritation and generating the urge-to-cough in humans is essentially unknown.

OBJECTIVES:

The aim of the present study was to use functional brain imaging to describe the supramedullary regions that are activated in humans during capsaicin inhalation.

METHODS:

Experiments were performed on 10 healthy subjects (5 males, 5 females). Capsaicin doses were individually tailored to evoke a transient and reversible urge-to-cough. Blood oxygen level-dependent (BOLD) functional magnetic resonance measures were collected during repeated 24-second challenges with capsaicin or saline inhalation and subjects were asked to rate the urge-to-cough intensity of each challenge.

MEASUREMENTS AND MAIN RESULTS:

Capsaicin inhalation reliably evoked an urge-to-cough, which was associated with activations in a variety of brain regions, including the insula cortex, anterior midcingulate cortex, primary sensory cortex, orbitofrontal cortex, supplementary motor area, and cerebellum.

CONCLUSIONS:

These data provide the first insights into the cortical neuronal network involved in sensing airway irritation and modulating coughing in humans.

PMID:
17575093
DOI:
10.1164/rccm.200612-1856OC
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center