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Bioorg Med Chem Lett. 2007 Aug 1;17(15):4378-81. Epub 2007 Mar 3.

SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.

Author information

1
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com

Abstract

Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.

PMID:
17574417
DOI:
10.1016/j.bmcl.2007.02.075
[Indexed for MEDLINE]

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