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Bioorg Med Chem Lett. 2007 Aug 15;17(16):4487-90. Epub 2007 Jun 6.

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

Author information

1
Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. mark.manfredi@bms.com

Abstract

Replacement of the 3-oxo group of 2-chloro-4-[(7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2c]imidazol-2(3H)-yl]-3-methylbenzonitrile resulted in a sulfamide series of selective androgen receptor modulator (SARM) agonists.

PMID:
17574413
DOI:
10.1016/j.bmcl.2007.06.007
[Indexed for MEDLINE]

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