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Cell. 2007 Jun 15;129(6):1041-3.

Taking vesicular transport to the cilium.

Author information

1
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. leroux@sfu.ca

Abstract

Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.

PMID:
17574016
DOI:
10.1016/j.cell.2007.05.049
[Indexed for MEDLINE]
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