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Eur J Pharmacol. 2007 Jul 30;568(1-3):16-24. Epub 2007 May 22.

Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis.

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Department of Food Science, University of Massachusetts Amherst, 100 Holdsworth Way, Amherst, MA 01003, United States.


Conjugated linoleic acid (CLA) has shown a variety of biologically beneficial effects. Dietary CLA inhibits eddosteal bone resorption, increases endocortical bone formation, and modulates the action and expression of cyclooxygenase (COX) enzyme, thereby decreasing prostaglandin-dependent bone resorption. CLA also enhances calcium absorption and may improve bone formation in animals, although results are not consistent. Since CLA can also affect inflammatory cytokines, it is hypothesized that CLA may be a good tool for prevention or reduction of rheumatoid arthritis symptoms. The possible mechanisms by which CLA prevents rheumatoid arthritis as well as other inflammatory diseases is discussed.

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