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Nat Rev Genet. 2007 Jul;8(7):497-506.

Genetic linkage and association analyses for trait mapping in Plasmodium falciparum.

Author information

1
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892-8132, USA.

Abstract

Genetic studies of Plasmodium falciparum laboratory crosses and field isolates have produced valuable insights into determinants of drug responses, antigenic variation, disease virulence, cellular development and population structures of these virulent human malaria parasites. Full-genome sequences and high-resolution haplotype maps of SNPs and microsatellites are now available for all 14 parasite chromosomes. Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease.

PMID:
17572690
DOI:
10.1038/nrg2126
[Indexed for MEDLINE]

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