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Nat Methods. 2007 Jul;4(7):551-3. Epub 2007 Jun 17.

Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors.

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1
Stem Cell Program, Hematology/Oncology, Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Zebrafish are a valuable vertebrate model to study carcinogenesis, but noninvasive imaging is challenging because adult fish are not transparent. Here we show that tumors could be readily detected in vivo using high-resolution microscopic ultrasound in zebrafish. We successfully obtained tissue perfusion calculations and cellular aspirates, and analyzed tumor progression and response to treatment. Ultrasound biomicroscopy allows longitudinal studies of tumor development and real-time assessment of therapeutic effects in zebrafish.

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PMID:
17572681
DOI:
10.1038/nmeth1059
[Indexed for MEDLINE]

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