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A brief review of short tandem repeat mutation.

Author information

1
Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China.

Abstract

Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.

PMID:
17572359
PMCID:
PMC5054066
DOI:
10.1016/S1672-0229(07)60009-6
[Indexed for MEDLINE]
Free PMC Article
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