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Psychiatry Res. 2007 Aug 15;155(3):265-9. Epub 2007 Jun 14.

Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study.

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Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia.


Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.

[Indexed for MEDLINE]

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