Send to

Choose Destination
Folia Microbiol (Praha). 2007;52(1):39-43.

Effect of subinhibitory concentration of some established and experimental antifungal compounds on the germ tube formation in Candida albicans.

Author information

Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czechia.


The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of three C. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center