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Dement Geriatr Cogn Disord. 2007;24(2):91-7. Epub 2007 Jun 14.

Structural correlates of apathy in Alzheimer's disease.

Author information

1
Department of Neurology, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. lapostolova@mednet.ucla.edu

Abstract

BACKGROUND:

Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described.

METHODS:

We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy.

RESULTS:

There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance.

CONCLUSION:

Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.

PMID:
17570907
DOI:
10.1159/000103914
[Indexed for MEDLINE]

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