Send to

Choose Destination
See comment in PubMed Commons below
Biol Chem. 2007 Jul;388(7):693-7.

The spliceosome: a ribozyme at heart?

Author information

  • 1Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA.


The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200 different proteins and five small nuclear RNAs (snRNAs). Extensive mechanistic and structural similarities to self-splicing group II introns, large ribozymes found in prokaryotes and lower eukaryotes that catalyze an identical reaction, strongly suggest that the spliceosomal RNAs are in fact the catalytic components of the spliceosome. Of the five spliceosomal RNAs, U2 and U6 are the only ones that are absolutely required for both steps of splicing. These two snRNAs form an elaborate base-paired complex that might in fact constitute the active site of the spliceosome.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for iFactory
    Loading ...
    Support Center