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Biol Chem. 2007 Jul;388(7):665-78.

Group II introns: structure, folding and splicing mechanism.

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1
Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. olga.fedorova@yale.edu

Abstract

Group II introns are large autocatalytic RNAs found in organellar genomes of plants and lower eukaryotes, as well as in some bacterial genomes. Interestingly, these ribozymes share characteristic traits with both spliceosomal introns and non-LTR retrotransposons and may have a common evolutionary ancestor. Furthermore, group II intron features such as structure, folding and catalytic mechanism differ considerably from those of other large ribozymes, making group II introns an attractive model system to gain novel insights into RNA biology and biochemistry. This review explores recent advances in the structural and mechanistic characterization of group II intron architecture and self-splicing.

PMID:
17570818
DOI:
10.1515/BC.2007.090
[Indexed for MEDLINE]
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