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J Infect Dis. 2007 Jul 15;196(2):208-11. Epub 2007 Jun 4.

Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects.

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Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.


To investigate a possible association between human herpesvirus 8 (HHV-8) and prostate cancer, we evaluated HHV-8 seroprevalence in 2 case-control studies. HHV-8 antibodies were detected by immunofluorescence with cells expressing lytic viral proteins and by enzyme immunoassays with recombinant viral structural protein (K8.1) and latent protein (latency-associated nuclear antigen-1; open reading frame 73), respectively. HHV-8 seroprevalence tended to be lower in patients with prostate cancer than in control subjects, but there was no significant difference in either study. These data imply that HHV-8 is not a major prevalent cause of prostate cancer.

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