Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Biosci. 2007 Sep 1;12:4788-99.

Slipped strand DNA structures.

Author information

1
Laboratory of DNA Structure and Mutagenesis, Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901-6975, USA. rsinden@fit.edu

Abstract

Slipped strand DNA structures are formed when complementary strands comprising direct repeats pair in a misaligned, or slipped, fashion along the DNA helix axis. Although slipped strand DNA may form in almost any direct repeat, to date, these structures have only been detected in short DNA repeats, termed unstable DNA repeats, in which expansion is associated with many neurodegenerative diseases. This alternative DNA structure, or a similar slipped intermediate DNA that may form during DNA replication or repair, may be a causative factor in the instability of the DNA sequences that can form these structures.

PMID:
17569609
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers in Bioscience
    Loading ...
    Support Center