Format

Send to

Choose Destination
See comment in PubMed Commons below
Ophthalmology. 2007 Dec;114(12):2221-6. Epub 2007 Jun 12.

Systemic antihypertensive medication and incident open-angle glaucoma.

Author information

1
Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Abstract

PURPOSE:

To determine the association between systemic antihypertensive medication and incident open-angle glaucoma.

DESIGN:

Prospective population-based cohort study.

PARTICIPANTS:

The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical ophthalmologic examinations at baseline and follow-up were available.

METHODS:

Use of antihypertensive medication was registered over an average follow-up period of 6.5 years. Associations between incident open-angle glaucoma and antihypertensive medication were assessed using multivariate logistic regression models adjusted for age, gender, duration of follow-up, intraocular pressure, intraocular pressure-lowering medication, and cardiovascular disease.

MAIN OUTCOME MEASURES:

Odds ratios of associations between incident open-angle glaucoma and use of antihypertensive medication.

RESULTS:

During follow-up, there were 87 incident cases of open-angle glaucoma. Participants using calcium channel antagonists had a 1.8-fold (95% confidence interval [CI], 1.04-3.2; P = 0.037) higher risk of developing incident open-angle glaucoma. beta-Blockers were associated with a nonsignificant risk reduction (odds ratio, 0.6; 95% CI, 0.3-1.02; P = 0.060). None of the other classes of antihypertensives was significantly associated with incident open-angle glaucoma.

CONCLUSIONS:

These data suggest that use of calcium channel antagonists is associated with open-angle glaucoma, but this requires confirmation. These results do not support the use of calcium channel antagonists for the treatment of normal-tension glaucoma.

PMID:
17568677
DOI:
10.1016/j.ophtha.2007.03.047
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center