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J Nat Prod. 2007 Jul;70(7):1214-7. Epub 2007 Jun 13.

Cerebrosides and tocopherol trimers from the seeds of Euryale ferox.

Author information

1
Fiber Research Division, Industrial Technology Research Institute, Hsinchu, Taiwan, 310, Republic of China.

Abstract

Two new cerebrosides, ferocerebrosides A (1) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxydocosanoyl)-4,8-sphingadienine] and B (2) [(2S,3R,4E,8E,2'R)-1-O-(beta-glucopyranosyl)-N-(2'-hydroxytetracosanoyl)-4,8-sphingadienine], two new tocopherol trimers, ferotocotrimers C (5) and D (6), and two known tocopherol trimers, IVb (3) and IVa (4), were isolated from the seeds of Euryale ferox. Their structures were determined on the basis of spectroscopic data, especially 1D and 2D NMR experiments. Compounds 1 and 2 showed cytotoxicity in the brine shrimp lethality bioassay, with LC50 values of 0.17 and 0.20 mM, respectively.

PMID:
17567070
DOI:
10.1021/np070095j
[Indexed for MEDLINE]

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