Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neurosurg. 2007 Jun;106(6 Suppl):484-9.

Calvarial defects associated with neurofibromatosis type 1. Report of two cases.

Author information

1
Department of Neurosurgery, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jmislow@partners.org

Abstract

Calvarial osteolysis is a relatively rare finding in patients with neurofibromatosis. The authors describe two patients with neurofibromatosis Type 1 (NF1) and extensive cranial defects associated with underlying dural ectasia. Cranioplasties were performed in both patients with mixed results. One patient underwent cranioplasty using titanium mesh and methylmethacrylate. The other patient underwent an extensive cranioplasty with autogenous iliac crest grafting, and after initial healing has since had further bone resorption. In conclusion, the results of cranial reconstruction in patients with NF1 and dural ectasia are unpredictable because of the tendency for further bone resorption; techniques that protect the graft material from cerebrospinal fluid pulsations via a rigid mesh should be considered.

PMID:
17566407
DOI:
10.3171/ped.2007.106.6.484
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center