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Am J Reprod Immunol. 2007 Jul;58(1):11-20.

The etiological role of allogeneic fetal rejection in pre-eclampsia.

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1
Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan. nharuki@fujita-hu.ac.jp

Abstract

PROBLEM:

It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia.

METHOD OF STUDY:

We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies.

RESULTS:

IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity.

CONCLUSION:

Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.

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