Double screening of suramin derivatives on human colon cancer cells and on neural cells provides new therapeutic agents with reduced toxicity

Cancer Lett. 1991 Dec 1;60(3):213-9. doi: 10.1016/0304-3835(91)90116-y.

Abstract

Suramin is a polyanionic compound currently used under evaluation for antineoplastic activity. One of the main problems encountered during clinical trials was an adverse neurotoxic effect, probably due to a direct cytotoxic effect on neural cells. Suramin is also known to trigger differentiation of human colon cancer cells, yet a chronic treatment induces a lysosomal storage disorder. The aim of this study was to evaluate suramin analogs for their effect: (i) on the lysosomal system of the human colon cancer cell clone HT29-D4; and (ii) on C6 glioma cell growth and morphology. One of the derivatives tested, NF036, induced terminal differentiation of HT29-D4 cells without any impairment of the lysosomal system. Furthermore, in contrast to suramin, NF036 did not alter C6 cell growth and morphology. We conclude that there is a relationship between the ability of a suramin derivative to induce a lysosomal storage disorder in human colon cancer cells and its neurotoxic effect. A double screening of suramin analogs on HT29-D4 and C6 cells allowed us to identify a new candidate antineoplastic drug: NF036.

Publication types

  • Comparative Study

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cell Division / drug effects
  • Cell Line
  • Cell Survival / drug effects*
  • Colonic Neoplasms
  • Drug Screening Assays, Antitumor
  • Glioma
  • Humans
  • Kinetics
  • Lysosomes / drug effects
  • Lysosomes / ultrastructure*
  • Structure-Activity Relationship
  • Suramin / analogs & derivatives*
  • Suramin / pharmacology*

Substances

  • Antineoplastic Agents
  • Suramin