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Cancer Genet Cytogenet. 1991 Oct 15;56(2):181-7.

Cytogenetic analysis of head and neck carcinomas.

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Department of Biological Sciences, St. John's University, Jamaica, NY.

Erratum in

  • Cancer Genet Cytogenet 1992 Feb;58(2):following 215.


Ten primary squamous cell carcinomas (SCC) of the head and neck were evaluated cytogenetically after 10-14 days of in vitro culture. Addition of 3% L-glutamine was essential for consistent epithelial growth of these carcinomas. Outgrowth of cells from tissue explants contained a mixture of chromosomally normal and abnormal cells; the abnormal cells had extensive changes including translocations, marker chromosomes, inversions, deletions, and duplications. In addition, all carcinomas contained cells with pulverization and double minute chromosomes (dmin). Chromosomes 11, 13, and 14 had "hotspots" of rearrangements.

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