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J Headache Pain. 2007 Jun;8(3):167-74. Epub 2007 Jun 11.

Effects of remote cutaneous pain on trigeminal laser-evoked potentials in migraine patients.

Author information

1
Neurophysiopathology of Chronic Pain Unit, Neurological and Psychiatric Sciences Department, University of Bari, Clinica Neurologica, Policlinico, Piazza Giulio Cesare 11, I-70124 Bari, Italy. m.detommaso@neurol.uniba.it

Abstract

The present study aimed to evaluate heat pain thresholds and evoked potentials following CO(2) laser thermal stimulation (laser-evoked potentials, LEPs), during remote application of capsaicin, in migraine patients vs. non-migraine healthy controls. Twelve outpatients suffering from migraine without aura were compared with 10 healthy controls. The LEPs were recorded by 6 scalp electrodes, stimulating the dorsum of the right hand and the right supraorbital zone in basal condition, during the application of 3% capsaicin on the dorsum of the left hand and after capsaicin removal. In normal subjects, the laser pain and the N2-P2 vertex complex obtained by the hand and face stimulation were significantly reduced during remote capsaicin application, with respect to pre-and post-capsaicin conditions, while in migraine LEPs and laser pain were not significantly modified during remote painful stimulation. In migraine a defective brainstem inhibiting control may coexist with cognitive factors of focalised attention to facial pain, less sensitive to distraction by a second pain.

PMID:
17563842
PMCID:
PMC3476143
DOI:
10.1007/s10194-007-0385-8
[Indexed for MEDLINE]
Free PMC Article

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