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Osteoarthritis Cartilage. 2007 Nov;15(11):1225-34. Epub 2007 Jun 11.

MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up.

Author information

1
Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107-0946, USA. Robert.Stahl@radiology.ucsf.edu

Abstract

OBJECTIVE:

To assess differences in magnetic resonance imaging (MRI)-based compositional (T2) and morphometric (volume and thickness) parameters of the tibio-femoral joint cartilage in subjects with and without osteoarthritis (OA) and compare these with clinical assessment tools during a 1-year follow-up.

METHOD:

Three Tesla MRI of the knee joint was performed in eight female patients (body mass index [BMI]>30) with early OA and 10 age-matched female controls (BMI<30) at baseline (BL) and after 3, 6 and 12 months. Cartilage T2 maps, volume and average thickness were calculated in five compartments (medial/lateral femoral condyle, medial/lateral tibia and trochlea). These data were correlated with changes in clinical parameters and joint space width determined in standardized knee radiographs using a mixed random effects model.

RESULTS:

At BL, T2 was significantly higher (P<0.05) across the cartilage in patients (45.68+/-5.17ms) compared to controls (41.75+/-4.33ms). Patients had significantly (P<0.05) less cartilage volume and less average cartilage thickness in the tibia than controls (2.10+/-0.53cm(3) vs 2.91+/-0.49cm(3) and 1.59+/-0.24mm vs 1.90+/-0.29mm, respectively). A significant change in clinical parameters of OA, cartilage T2 values or a decrease of volume and average thickness could not be demonstrated within both groups.

CONCLUSION:

Significant differences between the groups indicate that both T2 and morphometric parameters may be useful in quantifying early OA related changes. In a 12-month follow-up, however, no significant alterations of the studied parameters were found, which may be due to the length of the observation interval.

PMID:
17561417
DOI:
10.1016/j.joca.2007.04.018
[Indexed for MEDLINE]
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