Format

Send to

Choose Destination
Am J Surg. 2007 Jul;194(1):35-9.

Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis.

Author information

1
Department of Surgery, Klinikum rechts der Isar, Technische Universit├Ąt, Ismaninger Str. 22, 81675 Munich, Germany. novotny@chir.med.tu-muenchen.de

Abstract

BACKGROUND:

To develop strategies for the prediction of sepsis outcome systemic procalcitonin (PCT) levels were correlated with various clinical parameters.

METHODS:

PCT levels and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were assessed on the day of sepsis diagnosis in a large series (n = 160) of patients developing sepsis after major visceral surgery.

RESULTS:

In multivariate analysis, systemic PCT and the APACHE II score could be identified as independent early predictive indicators of lethal sepsis. Combining both indicators at sepsis onset, a prognosis score could be calculated using binary logistic regression analysis allowing the identification of high- and low-risk groups. While 71% of the high-risk patients died of sepsis, 77% of patients assigned to the low-risk group survived the septic complication (sensitivity 71%, specificity 77%).

CONCLUSION:

Calculation of the prognosis-score allowed for an early prediction of the septic course with high sensitivity and specificity. This information could aid in deciding on adequate treatment strategies.

PMID:
17560906
DOI:
10.1016/j.amjsurg.2006.10.026
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center