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Clin Dermatol. 2007 May-Jun;25(3):348-9.

In the pursuit of classifying severe cutaneous adverse reactions.

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The Dermatology Unit, Kaplan Medical Center, Rechovot, Israel. <>


We suggest adding an additional type of lesion to the existing 4 types of lesions of the erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), namely "flat typical target" and call the original typical targets "raised typical target." The EM group would consist of raised typical targets and raised atypical targets, similar to the original definition, and the SJS/TEN group would consist of flat typical targets, flat atypical targets and macules with or without blisters. In our proposed modified classification (Table 1), all the lesions that are found in the EM group are raised, whereas all lesions that characterize the SJS/TEN group are flat, even though they have blisters on them.

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