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Clin Dermatol. 2007 May-Jun;25(3):341-6.

Sarcoidosis, role of tumor necrosis factor inhibitors and other biologic agents, past, present, and future concepts.

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Section of Rheumatology & Immunology, University of Chicago, Chicago, IL 60637, USA. <>


Tumor necrosis factor is a potent cytokine involved in the inflammatory process of many diseases. Agents that block tumor necrosis factor have been used in the treatment of various immune-mediated diseases, including rheumatoid arthritis, Crohn disease, psoriatic arthritis, and ankylosing spondylitis. Sarcoidosis is an immune-mediated inflammatory disorder of unknown etiology characterized by the formation of noncaseating granulomas. Tumor necrosis factor plays a major role in the inflammatory process seen in sarcoidosis. Sarcoidosis therapies with activity against tumor necrosis factor and specific anti-tumor necrosis factor therapies have been used with variable success. The long-term safety and efficacy of such therapies are yet to be determined in well-designed clinical trials with long-term follow-up.

[Indexed for MEDLINE]

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