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Aging Male. 2007 Jun;10(2):53-6.

Testosterone deficiency and the metabolic syndrome.

Author information

1
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. blunenf@attglobal.net

Abstract

Evidence is presented to link components of the metabolic syndrome to testosterone deficiency and obesity. Testosterone deficiency in hypogonadism or testosterone deprivation in normo-gonadotropic men increases fat mass as well as fasting insulin levels. Testosterone supplementation (TS) in a dose dependent manner, increase lean body mass (LBM), reduces fat mass, body mass index (BMI) and waist hip ratio in both young and elderly hypogonadal men. A negative association between T and insulin resistance as well as impaired glucose intolerance has been demonstrated and in type 2 diabetic men TS improves metabolic parameters. TS improves most components of the metabolic syndrome and also reduces inflammatory cytokines.

PMID:
17558968
DOI:
10.1080/13685530701390800
[Indexed for MEDLINE]

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