Send to

Choose Destination
See comment in PubMed Commons below
Indian J Gastroenterol. 2007 Mar-Apr;26(2):70-3.

Effect of oral glutamine administration on oxidative stress, morbidity and mortality in critically ill surgical patients.

Author information

Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110 095, India.



To examine the effect of enteral administration of glutamine in patients with peritonitis or abdominal trauma.


In a prospective, interventional, observer-blind, randomized clinical trial, 120 patients, aged 18-60 years, were randomized to receive either enteral glutamine 45 g/day for 5 days in addition to standard care (n=63; group A) or standard care alone (n=57; group B). Surgical intervention was done as needed.


The two groups were comparable for sex and severity of illness scores. Following treatment, serum malondialdehyde (MDA) levels in group A increased from 4.4 (8.0) to 7.2 (4.8) mmol/mL, whereas those in group B decreased from 3.9 (4.9) to 3.1 (5.0) mmol/mL; these changes were not statistically significant. Reduced glutathione levels increased from 0.03 (0.04) to 0.06 (0.12) mg/g Hb (p=0.032) after treatment in group A and from 0.03 (0.03) to 0.05 (0.04) mg/g Hb (p=0.001) in group B. Infectious complications were equally frequent in the two groups (group A: 44; group B: 37; p=0.571). Survival rate and duration of hospital stay were also comparable in the two groups.


Enteral glutamine supplementation offers no advantage in patients with peritonitis or abdominal trauma.

Comment in

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center