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Wei Sheng Yan Jiu. 2007 Mar;36(2):152-4.

[Study of the mechanism of thyroid hormone disrupted by pentachlorophenol in FRTL-5 cell].

[Article in Chinese]

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  • 1Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China.



To study the mechanism of thyroid hormone action disrupted mechanism by pentachlorophenol in FRTL-5 cells.


In the study solvent control group (DMSO), positive control group in iodide uptake measurements (perchlorate sodium) and three pentachlorophenol groups were designed. FRTL-5 cells were treated at the doses of 0.1 microg/ml, 0.3 microg/ml and 0.5 microg/ml of pentachlorophenol for 24 hours. The proliferation of FRTL-5 cells was assayed by 3H - TdR, and the concentrations of thyroglobulin in culture were assayed by RIA. In iodide uptake measurements, and the 125I uptake of FRTL-5 cells was tested in 12 h and 24 h.


Pentachlorophenol had no effect on the proliferation of FRTL-5 cells, and the concentrations of thyroglobulin in culture were decreased at the levels of group 0.3 microg/ml and 0.5 microg/ml. The iodide uptakes of FRTL-5 cells were significantly increased at the levels of group 0.33 microg/ml and 0.5 microg/ml in 12 h. Perchlorate sodium made significant decreases of the iodide uptake of FRTL-5 cells in 12h and 24h.


The mechanism of the thyroid hormone action disrupted by pentachlorophenol may be associated with descreasing thyroglobulin in FRTL-5 cells.

[PubMed - indexed for MEDLINE]
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