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Cir Esp. 2007 Jun;81(6):345-7.

[Intraductal breast papillomas in patients with Costello syndrome].

[Article in Spanish]

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Servicio de Obstetricia y Ginecología, Hospital Virgen del Camino, Pamplona, Navarra, España.


Costello syndrome is a multisystemic congenital disorder with a very low prevalence. The pathogenesis remains unclear and predisposes to the development of tumors of ectodermal origin. Diagnosis is clinical, based on findings of mental and growth retardation and a characteristic phenotype. We report the case of a patient with Costello syndrome who was referred to our unit with a suspected diagnosis of intraductal papilloma based on the presence of various episodes of nipple discharge. Postoperative histopathological study confirmed the diagnosis of multiple intraductal papilloma. We review the literature on the topic and discuss the advisability of aggressive surgical therapy, given the predisposition of these patients to develop both benign and malignant tumors.

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