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J Proteome Res. 2007 Jul;6(7):2833-40. Epub 2007 Jun 7.

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

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1
Proteome Sciences PLC, Cobham, Surrey, United Kingdom.

Abstract

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

PMID:
17552550
DOI:
10.1021/pr0700753
[Indexed for MEDLINE]
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