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Nat Rev Neurosci. 2007 Jul;8(7):499-509.

Intracellular amyloid-beta in Alzheimer's disease.

Author information

1
Department of Neurobiology and Behaviour, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4545, USA. laferla@uci.edu

Abstract

The primal role that the amyloid-beta (Abeta) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that Abeta exists in multiple assembly states, which have different physiological or pathophysiological effects. Although the classical view is that Abeta is deposited extracellularly, emerging evidence from transgenic mice and human patients indicates that this peptide can also accumulate intraneuronally, which may contribute to disease progression.

PMID:
17551515
DOI:
10.1038/nrn2168
[Indexed for MEDLINE]

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