Send to

Choose Destination
See comment in PubMed Commons below
Arch Pathol Lab Med. 2007 Jun;131(6):866-71.

Activated protein C resistance and factor V Leiden: a review.

Author information

Department of Pathology, Brigham and Women's Hospital, Boston, Mass 02115, USA.



Factor V Leiden (FVL) is the most common heritable cause of venous thrombosis. It is caused by a single nucleotide substitution resulting in an R506Q missense mutation, resulting in factor V resistance to activated protein C (APC) inactivation. Carriers of FVL have an increased susceptibility to venous thrombosis, which is further increased in the presence of other genetic or environmental risk factors.


To review the biology, clinical findings, laboratory detection methods, and screening recommendations for patients with the FVL mutation.


PubMed review of published literature and online information.


FVL remains an important heritable cause of hypercoagulability since its discovery more than 10 years ago. Clinical suspicion should be high in cases of unexplained venous thrombosis. APC resistance and FVL mutation can be diagnosed with high sensitivity and specificity with use of clotting time-based functional assays and genetic assays, respectively, allowing for evidence-guided clinical decision making regarding the benefit of long-term anticoagulation.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Allen Press, Inc.
    Loading ...
    Support Center