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Transgenic Res. 2007 Dec;16(6):823-8. Epub 2007 Jun 5.

A mouse transgene drives embryonic dorsal posterior commissure expression.

Author information

1
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-0618, USA.

Abstract

In this report we generated mice co-transgenic for a minimal promoter LacZ construct and a mouse BAC from the gene poor region upstream of the Hoxd cluster. In addition to expression in the distal limb, genital bud, and spinal cord, we show that this BAC transgene also reproducibly drives unique bilateral, dorsal posterior commissure expression. The ability of this BAC to direct posterior commissure expression makes it worthy of further study as a valuable tool in transgenic/targeting experiments.

PMID:
17549599
DOI:
10.1007/s11248-007-9104-0
[Indexed for MEDLINE]

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