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J Clin Invest. 2007 Jun;117(6):1486-9.

Unchecked thrombin is bad news for troubled arteries.

Author information

  • 1Cardiovascular Research Institute, UCSF, San Francisco, California 94158-2517, USA. eric.camerer@ucsf.edu

Abstract

Thrombin is clearly a key trigger of thrombosis, the proximal cause of most morbidity and mortality in atherosclerotic cardiovascular disease. Might thrombin also contribute to longer-term, structural changes in the arterial wall that promote narrowing and clotting? A study in this issue of the JCI argues that it can. Aihara et al. report that haploinsufficiency of heparin cofactor II, a glycosaminoglycan-dependent thrombin inhibitor, exacerbates injury- or hyperlipidemia-induced arterial lesion formation in mice, possibly by excessive thrombin signaling through protease-activated receptors (see the related article beginning on page 1514).

PMID:
17549253
PMCID:
PMC1878539
DOI:
10.1172/JCI32473
[PubMed - indexed for MEDLINE]
Free PMC Article
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