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Infect Immun. 2007 Sep;75(9):4528-33. Epub 2007 Jun 4.

Mutation of traP in Staphylococcus aureus has no impact on expression of agr or biofilm formation.

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1
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham, Mail Slot 511, Little Rock, AR 72205, USA.

Abstract

To investigate the regulatory role of traP (target of RNAIII-activating peptide) in Staphylococcus aureus, we generated traP mutations in the clinical isolates UAMS-1 and USA300. In neither case did mutation of traP affect expression of the accessory gene regulator (agr) or the ability to form a biofilm. We were also unable to confirm that mutation of traP in the prototype 8325-4 laboratory strain RN6390 results in reduced expression of agr, reduced hemolytic activity, or an altered capacity to form a biofilm.

PMID:
17548479
PMCID:
PMC1951201
DOI:
10.1128/IAI.00603-07
[Indexed for MEDLINE]
Free PMC Article
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