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Int J Parasitol. 2007 Aug;37(10):1053-62. Epub 2007 Apr 29.

Leishmania MAP kinases--familiar proteins in an unusual context.

Author information

1
Bernhard Nocht Institute for Tropical Medicine, Parasitology Section, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany. martin.wiese@bni-hamburg.de

Abstract

Mitogen-activated protein kinases are well-known mediators of signal transduction of higher eukaryotes regulating important processes like proliferation, differentiation, stress response and apoptosis. In Leishmania, the typical three-tiered module of MAP kinase signal transduction pathways is present. However, typical activators like cell surface receptors and substrates such as RNA polymerase II transcription factors are missing. Here, I describe the set of 15 putative mitogen-activated protein kinases encoded in the Leishmania genome and discuss their potential function.

PMID:
17548090
DOI:
10.1016/j.ijpara.2007.04.008
[Indexed for MEDLINE]

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