Format

Send to

Choose Destination
Curr Diab Rep. 2007 Jun;7(3):223-7.

Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation.

Author information

1
Division of Endocrinology/Diabetes/Metabolism and the Clinical Research Center, Temple University Hospital, 3401 N. Broad Street, Philadelphia, PA 19140, USA. bodengh@tuhs.temple.edu

Abstract

Tissue factor (TF) is the primary initiator of blood coagulation. Circulating TF procoagulant activity (TF-PCA) is associated with blood cells and microparticles and is elevated in patients with type 2 diabetes mellitus. Combined hyperinsulinemia and hyperglycemia and to a lesser degree selective hyperinsulinemia for 24 hours in healthy volunteers increased circulating TF-PCA, monocyte TF surface expression and mRNA, plasma thrombin generation, and coagulation factors VII and VIII activities, suggesting that the coagulation system had been activated. In addition, platelet CD40L and platelet-monocyte aggregates increased, indicating platelet activation. Somatostatin abolished these changes. We conclude that hyperinsulinemia, but particularly the combination of hyperinsulinemia and hyperglycemia, creates a prothrombotic state and may, in addition, be proinflammatory and proatherogenic by virtue of the actions of CD40L and TF.

PMID:
17547839
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center