Format

Send to

Choose Destination
J Physiol Sci. 2007 Jun;57(3):187-92. Epub 2007 Jun 5.

Effect of chronic stress and L-carnitine on rat stomach.

Author information

1
Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey. nimetu@akdeniz.edu.tr

Abstract

BACKGROUND AND AIM:

L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury.

METHODS:

Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E(2) and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated.

RESULTS:

Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E(2) and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E(2), and mucus content in gastric mucosa, but it increased catalase activity.

CONCLUSIONS:

L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.

PMID:
17547782
DOI:
10.2170/physiolsci.RP004707
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Medical Tribune Inc.
Loading ...
Support Center