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Clin Liver Dis. 2007 Feb;11(1):191-207, x-xi.

Non-alcoholic steatohepatitis and cancer.

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1
Division of Gastro-Hepatology, Department of Internal Medicine, San Giovanni Battista Hospital, University of Turin, Turin, Italy. ebugianesi@yahoo.it

Abstract

Hepatocellular carcinoma (HCC) is part of the natural history of non-alcoholic steatohepatitis (NASH). A significant proportion of people who have cryptogenic cirrhosis develop HCC. NASH-related cirrhosis carries a substantial risk for early HCC development. Diagnosis of HCC often is made at first referral; the tumor usually is large with multiple localizations. Patients who have obesity or diabetes are at risk for HCC and a variety of cancers. Given the epidemic of obesity and diabetes, the incidence of NASH-related HCC is expected to increase. In addition to developing new diagnostic tools and pharmacologic therapies, efforts should be directed at preventing non-alcoholic fatty liver disease.

PMID:
17544979
DOI:
10.1016/j.cld.2007.02.006
[Indexed for MEDLINE]
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