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J Vasc Surg. 2007 Jun;45 Suppl A:A92-8.

Cytokines and the early vein graft: strategies to enhance durability.

Author information

  • 1University of Florida College of Medicine and the Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA. Ozaki@surgery.ufl.edu

Abstract

This brief review focuses on experimental studies linking the proinflammatory cytokine tumor necrosis factor-alpha to accelerated vein graft failure in the broader historical context of vein graft research. From some perspectives, the field appears ripe for transfer of cytokine knowledge and therapeutic approaches that have evolved in other systems to vascular surgery problems. However, the complexity of vein graft disease suggests that more robust research approaches, such as broadening of the scope beyond focus on single mediators and neointimal hyperplasia, will be necessary to reach translatable strategies to prolong human vein graft durability.

PMID:
17544029
PMCID:
PMC2031915
DOI:
10.1016/j.jvs.2007.02.032
[PubMed - indexed for MEDLINE]
Free PMC Article
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